Publications
15 selected publications
1. Trupp M, Arenas E, Fainzilber M, Nilsson A-S, Sieber B-A, Grigoriou M, Kilkenny C, SalaxarGrueso E, Pachnis V, Arumäe U, Sariola H, Saarma M & Ibañéz CF. (1996) Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature, 381, 785-789.
2. Rivera, C., Voipio, J., Payne, J.A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M. & Kaila, K. (1999) A K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397, 251-255.
3. Rossi, J., Luukko, K., Poteriaev, D., Laurikainen, A., Sun, Y.F., Laakso, T., Eerikäinen, S., Tuominen, R., Lakso, M., Rauvala, H., Arumäe, U., Pasternack, M., Saarma, M. & Airaksinen, M.S. (1999) Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFRa2, a functional neurturin receptor. Neuron 22, 243-252.
4. Meng X, Lindahl M, Hyvönen ME, Parvinen M, de Rooij DG, Hess MW, Raatikainen-Ahokas A, Sainio K, Rauvala H, Lakso M, Pichel JG, Westphal H, Saarma M and Sariola H. (2000). Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science 287: 1489-1493.
5. Lindholm, P., Voutilainen, M.H., Laurén, J., Peränen, J., Leppänen, V-M., Andressoo,J.-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., Tuominen, R. K. and Saarma, M. (2007) Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature, 448, 73-77.
6. Lonka-Nevalaita L, Lume M, Leppänen S, Jokitalo E, Peränen J and Saarma M. (2010) Characterization of the intracellular localization, processing and secretion of two GDNF splice isoforms. J. Neurosci. 30(34):11403-11413.
7. Bespalov MM, Sidorova Y A, Tumova S, Ahonen-Bishopp A, Magalhães AC, Kulesskiy E, Paveliev M, Rivera C, Rauvala H, and Saarma M. (2011) Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin and artemin J. Cell Biol. 192(1), 153-169.
8. Lindahl M, Danilova T, Palm E, Pulkkila P, Voikar V, Hakonen E, Ustinov J, Andressoo J-O, Harvery B, Otonkoski T, Rossi J and Saarma M. (2014). MANF is indispensable for the proliferation and survival of pancreatic β-cells. Cell Reports, 7(2):366-75. doi: 10.1016/j.celrep.2014.03.023.
9. Kopra, J, Vilenius, C, Grealish, S, Harma, M-A, Varendi, K, Lindholm, J, Castren, E, Voikar, V, Bjorklund, A, Piepponen, T. P, Saarma, M*, Andressoo, J-O*. (2015) GDNF is not required for catecholaminergic neuron survival in vivo. Nature Neuroscience 18 (3): 319-322. * Equal contribution.
10. Eesmaa A, Yu L-Y, Göös H, Nõges K, Kovaleva V, Hellman M, Zimmermann R, Jung M, Permi P, Varjosalo M, Lindholm P, Saarma M. (2021) The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J. Biol. Chem, Jan 15;100295. doi: 10.1016/j.jbc.2021.100295.
11. Jasmin M, Ahn EH, Voutilainen MH, Fombonne J, Guix C, Viljakainen T, Kang SS, Yu LY, Saarma M*, Mehlen P*, Ye K.* (2021) Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features. EMBO J. 2021 Feb 1;40(3): e105537. doi: 10.15252/embj.2020105537.PMID: 33351190.
* Shared senior authors
12. Mahato AK, Kopra J, Renko JM, Visnapuu T, Korhonen I, Pulkkinen N, Bespalov MM, Domanskyi A, Ronken E, Piepponen TP, Voutilainen MH, Tuominen RK, Karelson M, Sidorova YA, Saarma M. (2020) Glial cell line-derived neurotrophic factor receptor Rearranged during transfection agonist supports dopamine neurons in Vitro and enhances dopamine release In Vivo. Mov Disord.;35(2):245-255. doi: 10.1002/mds.27943. PMID:31840869
13. Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell. 2021: S0092-8674(21)00077-5. doi: 10.1016/j.cell.2021.01.034. PMID: 33606976
14. De Lorenzo F, Lüningschrör P, Nam J, Beckett L, Pilotto F, Galli E, Lindholm P, Rüdt von Collenberg C, Tii Mungwa S, Jablonka S, Kauder J, Thau-Habermann N, Petri S, Lindholm D, Saxena S, Sendtner M, Saarma M*, Voutilainen MH* (2023). CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress. Brain. Sep 1;146(9):3783-3799. doi: 10.1093/brain/awad087. *Equal contribution
15. Kovaleva V, Yu L-Y, Ivanova L, Shpironok O, Nam J, Eesmaa A, Kumpula E-P, Sakson S, Toots U, Ustav M, Huiskonen JT, Voutilainen MH, Lindholm P, Karelson M, Saarma M. (2023) MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α. Cell Reports, 2023;42(2):112066. doi: 10.1016/j.celrep.2023.112066.